Tag Archives: barcoded embryos

Barcodes Before Birth?

Scientists from Spain’s Universitat Autònoma de Barcelona (UAB) and their colleagues from the Spanish National Research Council, have successfully developed an identification system with barcoded embryos. Scientists physically tagged mouse embryos and oocytes (egg cells) with microsopic, silicon barcode labels in order to streamline in vitro fertilization and embryo transfer procedures.

The barcode labels, which are biologically innocuous, are microinjected into the region between the cell membrane and the zona pellucida of the mouse embryo and since the embryo exits the zona pellucida before entering the uterus, the barcode would be shed at that point.

In lab studies, labeled embryos were shown to develop normally up until the last stage preceding implantation. Researchers also studied how well the barcode labels stayed on throughout the development cycle, how easily they could be read with a standard microscope, how they could be eliminated after the shedding of the zona pellucida and how well they could stand up to the freezing and thawing of their host embryo.

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